Skelaxin (metaxalone) is available as 400 mg round, pale pink tablets and 800 mg oval, pink scored tablet.
Metaxalone designated as an adjunct to rest, physical therapy and other measures to alleviate the discomfort associated with acute, painful musculoskeletal system. The mechanism of action of this drug has not been clearly defined but may be related to its sedative properties. Metaxalone 800 mg not directly relax tense skeletal muscles.
CONTRAINDICATIONS Metaxalone 800 Mg:
Known hypersensitivity to any component of this product. Known tendency drug induced, hemolytic, or other anemias. Significantly renal or hepatic function.
WARNINGS Metaxalone 800 Mg:
Metaxalone may enhance the effects of alcohol and other CNS depressants.
Precautions Metaxalone 800 Mg:
Metaxalone should be administered with caution to patients with pre-existing liver damage. Serial liver function tests should be performed in these patients. False-positive tests Benedict, due to an unknown reducing substance, have been noted. Glucose-specific test will differentiate findings.
Common Metaxalone 800 mg side effects
Some relatively common side effects of Metaxalone 800 mg use include drowsiness, nausea, vomiting, feeling dizzy, dizziness, irritability, nervousness and anxiety. In general, these side effects are mild and disappear by themselves, as the body adjusts to the medication Metaxalone.
Other Metaxalone 800 mg side effects
Some other, less common side effects are also possible with Metaxalone 800 mg. One of the most rare side effect of anaphylactoid reaction. Some people also may experience jaundice, and the reaction by the immune system, such as hypersensitivity and skin rash. Those who experience any of these side effects should notify your doctor as soon as possible.
SIDE Metaxalone 800 Mg:
The most frequent reactions to Metaxalone 800 mg include:
• CNS: drowsiness, dizziness, headache, and nervousness or “irritability”
• Digestive: nausea, vomiting, gastrointestinal upset
• immune system: hypersensitivity reactions, rash with itching or without
• Hematologic: leukopenia, hemolytic anemia
• hepatobiliary jaundice.
Though rare, anaphylactoid reactions have been reported with Metaxalone
Information for patients
Metaxalone may impair mental and / or physical abilities required to perform hazardous tasks such as operating machinery or driving a car, especially when used with alcohol or other CNS depressants.
Interactions Metaxalone 800 Mg:
Metaxalone 800 mg may enhance the effects of alcohol, barbiturates and other sedatives CNS.
Carcinogenesis, Mutagenesis, Impairment of Fertility:
Metaxalone carcinogenic potential has not been determined.
PREGNANCY Metaxalone 800 Mg:
Reproduction studies in rats showed no evidence of impaired fertility or harm to the fetus due to Metaxalone 800 mg. Post marketing experience has not revealed evidence of fetal injury, but such experience can not exclude the possibility of infrequent or subtle damage to the fetus.
Safe use Metaxalone has not been established taking into account possible adverse effects on fetal development. Thus, Metaxalone tablets should not be used in women who are or may become pregnant and particularly during early pregnancy unless in the opinion of the doctor the potential benefits outweigh the possible hazards.
NURSING MOTHERS:
It is not known whether this drug is released in human milk. As a general rule, nursing should not be undertaken while the patient is on drugs because many drugs are highlighted in human milk. Pediatric use, safety and efficacy in children 12 years and below were not installed.
Dosage and administration:
The recommended dose for adults and children over 12 years in two 400 mg tablets (800 mg) or one 800 mg tablet three to four times a day.
Metaxalone store at controlled room temperature between 15 C and 30 C (59 F and 86 F).
Clinical pharmacology Metaxalone 800 Mg:
The mechanism of action Metaxalone 800 mg humans has not been established, but may be related to the general depression of the central nervous system. He has no direct effect on the contractile mechanism of striated muscle motor end plate or the nerve fiber.
The absolute bioavailability of metaxalone from Skelaxin tablets is not known. Skelaxin (metaxalone) is metabolized in the liver and excreted in the urine as unidentified metabolites. Influence of age, gender, hepatic and renal failure on the pharmacokinetics of Skelaxin (metaxalone) has not been determined. In the absence of such information, Skelaxin (metaxalone) should be used with caution in patients with hepatic and / or renal failure and the elderly.
Overdose Metaxalone 800 Mg:
Deaths by deliberate or accidental overdose have occurred with this class of drugs, particularly incombination with antidepressants and / or alcohol.
In determining the LD50 in rats and mice, progressive sedation, hypnosis, and, finally, respiratoryfailure were noted as the dose increased. In dogs, no LD50 could be determined as the higher doses produced the emetic action in 15 to 30 minutes.
Overdose Treatment: gastric lavage and supportive therapy. Consultation with the regional poison control center is recommended.
